BRAMWELL follows the fortunes of Dr. Eleanor Bramwell (Jemma Redgrave) in her pursuit of public health and private amours in Victorian-era London. Feisty and unconventional, her sights are set on becoming a leading surgeon, an ambition unheard of for women in Victorian society. Eleanor's father Robert (David Calder) would like his daughter to join him in his respectable private practice, but his daughter has plans of her own which take her from the drawing rooms of the elite to the shocking deprivation of the slums of London's East End. This lavish period drama begins with Eleanor assisting at the East London Hospital of eminent surgeon Sir Herbert Hamilton. From the very beginning Eleanor's strongly held opinions and desire to take the medical profession out of the dark ages draw her into conflict with Sir Hamilton's old fashioned and often barbaric practices. But Eleanor's energy and compassion also win her friends, including Lady Cora Peters who recognizes Eleanor's talents and sets her up in a small charitable infirmary in the slums of the East End where she will encounter the difficulties and dangers of attending to the needs of both London's poor and criminal underworld