Fifty years after Tobe Hooper's The Texas Chain Saw Massacre shocked the world and forever changed the face of global cinema and popular culture, CHAIN REACTIONS charts the film's profound impact and lasting influence on five great artists - Patton Oswalt, Takashi Miike, Alexandra Heller-Nicholas, Stephen King, and Karyn Kusama - through early memories, sensory experiences, and childhood trauma. By crafting a dynamic dialogue between contemporary footage and never-before-seen outtakes, and delving into personal impressions triggered by distinct audiovisual formats, CHAIN REACTIONS goes to the heart of how a scruffy, no-budget independent film wormed its way into our collective nightmares and permanently altered the zeitgeist.