Coffy (Pam Grier) is a dedicated and passionate nurse who seeks revenge on the drug dealers who have devastated her community. When her younger sister becomes a victim of the drug trade, Coffy takes matters into her own hands, going undercover as a vigilante to dismantle the criminal underworld. As Coffy infiltrates the narcotics ring, she uses her intelligence, beauty, and martial arts skills to navigate a dangerous and corrupt world. Along the way, she forms alliances with both law enforcement and the criminal elements, blurring the lines between justice and revenge.