It is not a sequel to the German expressionist classic The Cabinet of Dr. Caligari. Rather it is almost a parody of the original. The story centers on the nymphomaniacal granddaughter of the nefarious Caligari. She has become a psychiatrist and runs the CIA (Caligari Insane Asylum), an institution built upon a toxic waste dump. Everything about this place, from the buildings to the staff to the patients themselves are strange. The beautiful Dr. Caligari is the strangest of all. When not attending to her regular duties, she continues to perform the brain research that will one day allow her to absorb the intelligence of her genius ancestor whose brain is preserved in a jar. She believes the key is in the fluids of grandpa's brain. She begins experimenting with herself and then on others.