When ace detective Harry Goodman goes mysteriously missing, his son Tim (Justice Smith) embarks on a journey to find out what happened. Aiding in the investigation is Harry's former Pokemon partner, Detective Pikachu (Ryan Reynolds), a hilariously wise-cracking, adorable super-sleuth. Finding that they are uniquely equipped to work together, as Tim is the only human who can talk with Pikachu, they join forces on a thrilling adventure to unravel the tangled mystery. Chasing clues together through the neon-lit streets of Ryme City a sprawling, modern metropolis where humans and Pokemon live side by side in a hyper-realistic live-action world they encounter a diverse cast of Pokemon characters and uncover a shocking plot that could destroy this peaceful co-existence and threaten the whole Pokemon universe.