In Anne Fletcher's family comedy, Barbra Streisand plays Joyce Brewster, a sixtysomething widow who has given up on men and seems to spend most of her free time phoning her son Andrew (Seth Rogen), a chemist who has created an all-natural cleaning solution that he's bet his career on and is trying to sell to retailers (a wager that he's losing thus far). As the movie opens, Andrew returns home to spend some time with his mom before going on a cross-country road trip to pitch his product in various cities, ending with a trip to Las Vegas where he'll shoot a Home Shopping Network demo.