The Substance is a body horror film directed by Coralie Fargeat and starring Demi Moore alongside Margaret Qualley. Centered on a radical and dangerous self-improvement procedure, the film explores obsession, identity, and bodily autonomy through extreme physical transformation. Blending satirical elements with visceral horror, it delivers an uncompromising critique of beauty culture and self-worth. Från IMDB: A fading celebrity takes a black-market drug: a cell-replicating substance that creates a younger, better version of herself.